On February 16, 2007, "Straight Jack," a track featuring Missy Elliott and produced by Polow da Don was leaked.The track entered the Deutsche Black Chart in at #35. In 2012, Thomas appeared as the leading lady in R&B singer Tyrese's music video for his single "Nothing On You." In 2016, she released a new solo single "Body" which served to promote her new fitness workout campaign. In 1991, she joined TLC, replacing founding member Crystal Jones, and was nicknamed "Chilli" by Lisa Lopes so that the group could retain the name TLC.The group went on to sell over 65 million records worldwide and became the second best selling group in the world and first in the US girl groups of all-time.Thomas made guest appearances on television shows such as The Parkers, That 70s Show, Living Single and Strong Medicine.
She ceased production when work began on the next TLC album, 3D (2002).In 2006, rumors of having signed a four-album deal with singer/rapper Akon's label Kon Live Distribution in 2006, she later denied these reports and confirmed that she was entertaining offers from other record labels.