Attention to qualitative changes in 8 morphological factors is most useful in dating the endometrial biopsy.
During the 1st week of luteal activity, attention should be focused on changes occurring in gland epithelium: gland mitosis, pseudostratification of nuclei, basal vacuolation, and secretion.
Although carefully collected, accuracy cannot be guaranteed. Differing provisions from the publisher's actual policy or licence agreement may be applicable.
When these same slides were reviewed by a single observer and the date for the most advanced area of the biopsy was used, 179 patients (60%) menstruated within 1 day of prediction.To determine whether biopsy caused early menstruation, the secretory phases of the 25 patients who had recorded temperatures in at least 2 cycles in addition to that in which the biopsy was taken were examined.These critera were used in 300 sterility biopsies taken from normally menstruating women over a 3-year period.Absence of organic endometrial disease and availability of accurate menstrual history were the only selection criteria. 42 of the 300 patients (14%) menstruated on the day predicted, 36 (12%) menstruated later, and 222 (74%) menstruated earlier.
During the 2nd week , stromal changes (including edema), predecidual reaction, stromal mitosis, and leukocytic infiltration are the key criteria.Tissue from the fundus of the uterus gives the most reliable information.