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Attention to qualitative changes in 8 morphological factors is most useful in dating the endometrial biopsy.

During the 1st week of luteal activity, attention should be focused on changes occurring in gland epithelium: gland mitosis, pseudostratification of nuclei, basal vacuolation, and secretion.

Although carefully collected, accuracy cannot be guaranteed. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

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When these same slides were reviewed by a single observer and the date for the most advanced area of the biopsy was used, 179 patients (60%) menstruated within 1 day of prediction.To determine whether biopsy caused early menstruation, the secretory phases of the 25 patients who had recorded temperatures in at least 2 cycles in addition to that in which the biopsy was taken were examined.These critera were used in 300 sterility biopsies taken from normally menstruating women over a 3-year period.Absence of organic endometrial disease and availability of accurate menstrual history were the only selection criteria. 42 of the 300 patients (14%) menstruated on the day predicted, 36 (12%) menstruated later, and 222 (74%) menstruated earlier.

During the 2nd week , stromal changes (including edema), predecidual reaction, stromal mitosis, and leukocytic infiltration are the key criteria.Tissue from the fundus of the uterus gives the most reliable information.

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