She filmed Sakura Memories (櫻紅醉了) – a TVB travel documentary programme about Japan – in the spring of 2009 and it aired on TVB in August 2009.Niki signed with BMA Records in 2005 and released her debut EP Pure Niki in the August of that year. She is also the author of several books, including Girlfriend Diary《周麗淇·女朋友手記》(2005), a book of the same title as her 2006 album The Child Woman 《The Child Woman》(2006), Detailed Little Things 《細味心事》(2007), Happiness 《幸福》(2009), and Cherish 《珍惜》(2010). In 2006, she released Child-Woman and a single Nikikaka. In August 2010, she released a charity single Make a Wish with proceeds donated to an organization called Make-A-Wish Hong Kong.
She is well known for her role and performance in Producer Lau Ka Ho's 2005 series The Gentle Crackdown (秀才遇著兵), which stars Moses Chan and her.She won the Most Improved Actress award at the TVB Anniversary Awards (2005) for her performance in The Gentle Crackdown.